The Penn Glee Club singers and accompanists perform at many notable University functions and events at top venues around Philadelphia and the world. Their repertoire includes choral standards, popular songs, Renaissance madrigals, sea shanties, and University songs.

The Penn Glee Club Band is Penn's premiere cover band consisting of a rhythm section, a horn section, and vocalists. It arranges and performs for a variety of gigs and parties around campus, on road trips, international and domestic tours, and in the downtown Philly area.

The Penn Glee Club Tech Crew is a group of creative students who work behind the scenes of Glee Club shows and other arts performances. Tech members work with lights, sound, sets, stage management, costumes, props, photography, and more.

The Penn Pipers, founded in 1950, is the oldest a cappella group at the University of Pennsylvania. A subset of the Penn Glee Club, it covers a wide range of music, from doo-wop, barbershop and vocal jazz, to contemporary and pop songs.

The Penn Sirens, founded in 2011, is the premier SSAA vocal ensemble at the University of Pennsylvania. A subset of the Penn Glee Club, it performs a vast array of engaging and diverse music, from traditional choral, jazz, and Broadway to contemporary pop and rock.